Arginine and sepsis

Sepsis impairs the intestinal absorption of amino acids by affecting the transporters. Analysis of the transport kinetics suggests that the decreased transport capacity is caused by a reduction in the number or affinity of the transporter proteins.

TABLE 6.1

Immune Effects of Arginine

Action

Animals Humans

Mitogenic response of lymphocytes

  • Health Yes
  • Injury or stress Yes Allograft rejection Yes Number of T cells, mitogenic reactivity, and delayed-type Yesb hypersensitivity responses in immunocomprised host

Antitumor cytotoxicity in vitro Yes

Antitumor response in vivo Yes

Response to sepsis Yes aNot done.

bAthymic nude animals. cHIV infected.

Yes Yes NDa

Yesc

Yes ND ND

Systemic Sepsis or Endotoxemia

Was this article helpful?

0 0

Post a comment