Suppression of Plasma Uric Acid by Inhibiting Xanthine Oxidase

Several pu-erh tea consumers have claimed that drinking pu-erh tea, especially aged pu-erh tea, can attenuate the pain of gout at the bone joint . The mechanism of this interesting clinical effect of pu-erh tea may come from the inhibitory effects of tea polyphenols on the uric acid-generating enzyme xanthine oxidase (XO) . The inhibitory effects of six tea polyphenols, namely, theaflavin (TF1), theaflavin-3-gallate (TF2), theaflavin-3,3'-digallate (TF3), epigallocatechin gallate (EGCG), gallic acid, and propyl gallate, on XO have been investigated 11 These six antioxidant compounds reduce oxidative stress in HL-60 cells . Theaflavins and EGCG inhibit XO to produce uric acid and also act as scavengers of superoxide TF3 acts as a competitive inhibitor and is the most potent inhibitor of XO among these compounds . It has been shown that pu-erh tea contains different levels of theaflavins, thearubigins, and higher polymerized catechins Therefore, pu-erh tea is expected to inhibit the XO activity through its polyphenol constituents

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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