GABA and Depression

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Depression is one of the most common conditions in the UK, affecting one in five people at some stage in their life . The World Health Organization (WHO) estimates that by 2020 depression will be the biggest global health concern after chronic heart disease Depression occurs in children, adolescents, women in menopause, the elderly, or those with mental disorder, especially in menopause 27,28 The symptom of depression in menopause will cause mood obstacles about 10 years later 28,29

Evidence from preclinical and clinical data suggests that GABA plays a role both in the pathophysiology of depression and bipolar disorder and in the mechanisms of action of antidepressant agents 30,31 Low GABA concentrations and receptor activity in the brain cause depression, palpitation, insomnia, learning disorders, and memory failure .29,32-34 GABA concentration in the CSF is inversely correlated with the severity of depression 35

Murphy et al . 36 found that during the treatment process for menopause disorder by estrogen replacement (such as estradiol), expression of the GABA receptor, GAD of the hippocampus neuron, and synthesis of GABA decreased in the rat brain Even for alcoholism, the GABA content in plasma decreased and the symptoms of neurosis (anorexia, sense of pain) and mental disorder (depression, mania, anxiety) were significant 37 Therefore, supply of GABA and enhancement of activity of the GABA receptor improve depression 30,31

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