Alcoholism is a major social, economic, and public health problem Social need and abuse of alcohol induced the development of tolerance and dependence A literature survey on ethanol and alcoholism indicates that GABA is an important target of ethanol in the CNS . Drinking ethanol alters the activity of GABA . Thus, it is speculated that the initial excitatory effect of ethanol may be due to the inhibition of GABAergic activity and decrease of GABA secretion in the brain .45
Some studies (human, animal, and in vitro test) have found an inverse correlation between GABA level in plasma and alcoholism .46-52 Gomez and Barros14 reported a low GABA concentration in the plasma of alcohol abusers and alcoholics Drinking alcohol alters the activity of the GABA-containing system in several ways, and may have a bearing on the clinical syndromes associated with alcohol abuse 53,54 Plasma GABA was lower in alcoholics than in nonalcoholic drinkers . Others have reported a low GABA concentration in the plasma of alcoholics55 and their sons 56 Therefore, drinking alcohol for a long time will alter synthesis, release, and metabolism of GABA, which will change GABA concentration in plasma and the brain Furthermore, through use of GABA-mimetic agents in animals it was found that these agents could inhibit seizures and stop pain 45 The higher activity of the GABA inhibitor in the brain could increase alcohol intake . 57,58
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Alcoholism is something that can't be formed in easy terms. Alcoholism as a whole refers to the circumstance whereby there's an obsession in man to keep ingesting beverages with alcohol content which is injurious to health. The circumstance of alcoholism doesn't let the person addicted have any command over ingestion despite being cognizant of the damaging consequences ensuing from it.