Wound Healing

Similar to muscle-wasting conditions, HMB has been tested with two amino acids to determine if wound healing is improved.52 Wound healing requires immune activation, cell proliferation, and protein synthesis,53-55 and the combination of HMB with arginine and glutamine supports these cell functions. Williams et al.52 studied the effects of HMB, arginine, and glutamine on wound healing, where a simulated model of wound healing was used. In this model, small subcutaneous catheters were inserted into the deltoid region of the subject's arm. After 2 weeks, the catheters were removed and analyzed for hydroxy-proline (OHP), an indicator of collagen synthesis. The researchers noted that the supplements were well tolerated and that no adverse events were reported during the supplementation period. The results showed that supplementation with HMB, arginine, and glutamine increased collagen synthesis by 67% over that of a placebo-supplemented group (p < 0.03). It was concluded from the study that the nutritional mixture of HMB, arginine, and glutamine would provide a safe nutritional means to increase wound healing in patients.

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