Glucose Regulation

Glutamine is as important as lactate in contributing to the net gluconeogenesis in the postabsorptive state, contributing to 20 to 25% of the whole-body glucose production. Glutamine gluconeogenesis contributes to approximately 5% of the systemic glucose appearance, and renal production of glucose from glutamine accounts for nearly 75% of all glucose derived from glutamine.8 However, in trained cyclists, glutamine supplementation did not show any significant impact on the rate of glycogen resynthesis, i.e., muscle glycogen concentrations, despite a twofold increase in plasma glutamine concentrations,9 suggesting that the impact of glutamine supplementation on glycogen synthesis post-exercise needs to be further evaluated.

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