Chondroitin Sulfate

There are no known or reported contraindications to chondroitin sulfate supplementation. Concerns have been expressed for the theoretical possibility that chondroitin sulfate may have antithrombotic activity and should be avoided by those with hemophilia and those taking anticoagulants, such as warfarin. It may also be immunosuppressive.49 Since the most common form sold is a salt, those on salt-restricted diets should use a salt-free supplement. Because there are no data, children and pregnant or nursing women should avoid consumption.6

Side effects are few and are usually mild digestive problems such as nausea, heartburn, and diarrhea. No allergic reactions have been reported.6 There are no known interactions with any other nutritional supplement, drug, herb, or food. If chitosan is taken, it may decrease absorption. There are no reports of overdosage. Biochemical, hemostatic, and hematological measurements indicate that it is safe.48 The usual dose recommended for benefit is 1200 mg.

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