Extensive blood chemistry (approximately 30 parameters) and hematology (approximately 20 parameters) data were reported. Supplemental HMB had no negative effects on any of these serum parameters when compared with the placebo-supplemented subjects. Blood potassium was minimally (<2%) but significantly (p < 0.01) decreased in HMB-supplemented subjects. This may have been due to the difference in mineral intakes between the treatment groups, as the HMB-supplemented group had a daily intake of 400 mg of calcium, 135 mg of phosphorous, and 170 mg of potassium, whereas the placebo group was not balanced for these nutrients. Blood hematology parameters measured during the studies included white blood cells (WBCs), red blood cells (RBCs), hemoglobin, hematocrit, platelets, and WBC subclasses. The only effect of HMB supplementation on any of these parameters was a small (p < 0.05) 0.5% decrease in hematocrit; however, no significant difference was noted in initial or ending values for hematocrit for the HMB- and placebo-supplemented groups.
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