ARG Supplementation and Nitric Oxide NO Production

In a double-blind study, Schaefer et al., using intravenous L-ARG hydrochloride salt, found that the ARG load significantly decreased peak plasma ammonia and lactate during exercise, suggesting that the increase in NO production was the mechanism.20

McConell et al. found ARG infusion to significantly increase skeletal muscle glucose clearance, believing that ARG's ability to increase NO production may have been responsible.21

For more details on both studies, and rationale for NO in exercise, see AA blends (Section 15.7) and NO sections (Section 15.7.2.4 and Section 15.7.3.4).

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