Folate and nonneural tube defect birth defects

In addition to the well-established relationship between folate and NTDs, the etiology of other birth defects may also be related to impaired folate status. A key example are the research findings that suggest that periconceptional use of multivitamins containing folic acid is associated with a reduction in the occurrence of congenital heart defects [23]. Although the data are less convincing, periconceptional folate may be related to a reduced occurrence of orofacial clefts as well [23].

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