Choline is a component of acetylcholine, which is a neurotransmitter of great importance to skeletal muscle activity. First, nerve cells reaching skeletal muscle cells release acetylcholine, which then stimulates muscle cells to contract. Furthermore, choline is a component of phosphotidyl-choline which is a structural component of muscle cell membranes. Choline, along with betaine (trimethylglycine [TMG]), dimethylglycine, sarcosine (N-methylglycine), methionine, and S-adenylsyl methionine, is involved in some of the processes that build several molecules which may be important for muscle performance, such as creatine and nucleic acids. Choline supplementation for the purposes of enhancing athletic performance (with and without other substances) requires further study.
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