Nacetyl Lcysteine NAC

Mercury causes a loss of glutathione, a vital antioxidant molecule caused by mercury binding to the sulfhydral chemical groups in the glutathione molecule. Remember, glutathione is lost in most neurodegenerative diseases long before clinical symptoms begin to appear. N-acetyl L-cysteine, commonly called NAC for short, can effectively chelate mercury. It is also a very effective and safe way to improve cellular glutathione levels.

Unfortunately, recent evidence indicates that NAC may actually worsen the neurological effects of mercury by increasing brain levels of the toxic metal.102 It does this by binding to the mercury in the blood and tissues and re-distributing it back into the nervous system, acting as a carrier for mercury. Since no one has shown that mercury, when bound to NAC, is harmful, I would recommend a limit of 500 mg a day for an adult.

Fortunately, mercury is carried into the brain by using one of the amino acid carrier sites (large neutral amino acid transport system (LNAA). Normally, the various amino acids compete with each other for use of these carrier sites, and the branch chain amino acids (leucine, isoleucine and valine) share the same carrier used by mercury when it is bound to NAC. It has been proposed that, to prevent NAC-chelated mercury from entering the brain, one might increase the intake of branched-chained amino acids in the diet, which include L-leucine, L-valine, and L-isoleucine. Other amino acids, such as L-tyrosine, L-phenylalanine and L-tryptophan, can also inhibit uptake of mercury into the brain, but some may have significant side effects of their own. I prefer the branched-chained amino acids. L-methio-nine also competes with mercury for absorption, but is less effective.

Because cellular glutathione is so vital to cell function and protection, and NAC is one of the more efficient ways to increase cellular glutathione levels, it should be used, but in lower doses, and in conjunction with the branched-chained amino acids. Alpha-lipoic acid also increases glutathione levels, so that the two work together.

I would recommend taking limited amounts of NAC during therapy, until this controversy is settled.

100 mg twice a day from eight to thirteen years of age. 250 mg daily for age fourteen to eighteen. 500 mg daily after age eighteen.

The branched-chained amino acids can be purchased as a combination of leucine, valine, and isoleucine or you can use L-leucine alone. L-leucine can cause hypoglycemia at any age. Should you develop the symptoms of hypoglycemia, such as nervousness, trembling, and anxiety, stop taking it. Take only during the course of treatment. Also, do not give l-leucine to infants and small children because of the danger of hypoglycemia. Otherwise, the dose should be:

From ages four to ten: add 250 mg to food at dinner. Ages eleven to sixteen: add 500 mg to each meal. Adults: 1,000 mg with each meal.

0 0

Post a comment