Alpha Lipoic Acid

This is a truly a remarkable substance that provides many protective functions. Most important for mercury toxicity is that alpha-lipoic acid is a very powerful antioxidant and, in addition, binds tightly to mercury even in the nervous system, neutralizing its toxicity. Alpha-lipoic acid easily penetrates the blood-brain barrier, so that it can reach into the brain to remove the damaging metal.

Alpha-lipoic acid also increases cellular levels of glutathione, a major neutralizing molecule for mercury; it enhances cellular energy production, is a powerful and versatile antioxidant (as dehydrolipoic acid or DHLA), and chelates iron.

In general, in adults the doses needed to remove mercury from the brain are very high, 600-800 mg a day. Intravenous doses have been attempted, but it is very difficult to dissolve alpha-lipoic acid in water. Significant hypoglycemia can be a problem with large intravenous doses and can occur with R-lipoic acid taken on an empty stomach. I usually suggest taking three to four small doses daily, rather than a single large dose. Suggested dose based on weight in kilograms is 10 mg/kg/day.

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