Curcumin

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl) 1,6-heptadiene-3,5-dione), the major pigment in the spice tumeric, which is derived from Curcuma longa, inhibits the growth of the colon adeno-carcinoma cell lines HT29 and HCT15 (Hanif et al., 1997) and suppresses tumorigenesis in the intestine of both the azoxymethane-induced F344 rat model (Kawamori et al., 1999) and in the Apcmin mouse (Mahmoud et al., 2000). These anti-neoplastic effects are associated with decreased activation of the transcription factor NF-kB (Singh and Aggarwal, 1995) and promotion of apoptosis both in vitro (Kuo et al., 1996) and in vivo (Samaha et al., 1997). Exposure of Apcmm mice to PhIP (2-amino 1-methyl-6-phenylimidazo(4,5-b) pyridine - the most abundant heterocyclic amine in cooked meat) doubled tumour multiplicity in the proximal small bowel and was accompanied by only half the rate of mucosal cell apoptosis that was seen in wild-type C57Bl/6 animals (Figs 6.3 and 6.4) (Collett et al., 2001). Curcumin treatment partially attenuated the resistance to PhIP-induced apoptosis observed in the Apcmm mice and inhibited PhIP-induced tumorigenesis in the co E o c ffi

Fig. 6.3. Adenoma multiplicity (tumours per mouse) in the proximal small intestine of ApC"'" mice treated with curcumin and/or PhIP for 10 weeks from weaning (Collett et al., 2001).

Control

Curcumin

PhIP

PhIP + Curcumin

Fig. 6.3. Adenoma multiplicity (tumours per mouse) in the proximal small intestine of ApC"'" mice treated with curcumin and/or PhIP for 10 weeks from weaning (Collett et al., 2001).

Control

Curcumin

PhIP

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