Growth hormone is secreted by the anterior pituitary. Its secretion is enhanced by hypoglycemia. It has direct and indirect effects on decreasing glucose uptake in specific tissues such as muscle. Part of this effect may be due to the liberation of fatty acids from adipose tissue, which then inhibit glucose metabolism. If growth hormone is chronically administered, it causes persistent hyperglycemia, which stimulates the insulin secretion. The b cells, however, finally become exhausted, and diabetes ensues.
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