GLUT Hepatic Microsomal Glucose Transporter

The existence of GLUT 7 has been reported. Unlike the others, it is an internal or intracellular transporter, possibly involved in the glucose-6-phosphatase complex found in the endoplasmic reticulum of hepatocytes. Glucose is produced in the liver by glycogenolysis and gluconeogenesis. The last stage of each of these processes is the removal of a phosphate group from glucose by the multicomponent enzyme glucose-6-phosphatase; the resultant free glucose is liberated into the lumen of the endoplasmic reticulum. To export the glucose into the bloodstream it must be transferred across the endoplasmic reticulum membrane. The transporter that does this job is called GLUT 7 (23). It has 65% identity of amino acids with GLUT 2. There is a unique sequence of 6 amino acids at the C terminus of GLUT 7 that appears to be involved in keeping the transporter in the endoplasmic reticulum membrane (19).

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