Chronic intakes of up to 5mg fluoride/day in healthy adults appear to be safe. As intakes rise above this level, toxicity occurs. The first sign is dental fluorosis, in which the excess fluoride interferes with mineralization of the enamel and produces weakened, stained, and pitted enamel. Ingestion of more than 8-10 mg fluoride/day may produce skeletal deformities, osteoporosis, and osteomalacia, along with secondary hyperparathyroidism and calcification of soft tissues.2 3


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As sodium fluoride At bedtime, after brushing teeth11

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