At doses of 400-800 mg/day in healthy persons, vitamin E is nontoxic. Daily doses of 1600-3200 mg have been used for prolonged periods without significant side effects.4 People taking anticoagulant drugs should be cautious with high doses, however. Vitamin E may enhance the effects of anticoagulants and decrease levels of vitamin K-dependent clotting factors. People with diabetes should be cautious when starting high doses of vitamin E because the vitamin may enhance the action of insulin and, rarely, produce hypoglycemia.

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