Hypoglycemia

Oversecretion of insulin in response to meals produces a disorder termed "reactive hypo-glycemia." In reactive hypoglycemia meals rich in simple sugars and refined carbohydrates stimulate a large insulin response; the insulin then pushes down blood glucose to below normal levels.16 Symptoms most often occur mid-morning and mid-to-late-after noon, usually 2-4 hours after eating a carbohydrate-rich meal. Because the brain depends on a steady supply of glucose, hypoglycemia impairs mentation, alertness, and concentration. Reactive hypoglycemia may cause fatigue and irritability.

Reactive hypoglycemia can produce the following symptoms:

Fig. 5.12: Nicotinamide in newly diagnosed type 1 diabetes. Meta-analysis of 10 randomized trials involving more than 200 newly diagnosed, nicotinamide-treated type 1 diabetic patients. One year after diagnosis baseline C-peptide (a measure of beta-cell function) was significantly higher in nicotinamide-treated pateints, compared with controls.

  • Adapted from Pozzilli P, et al. Diabetes Care. 1996;19:1357)
  • Chromium 1 mg/d
  • Chromium 200 mcg/d
  • Placebo
  • Chromium 1 mg/d
  • Chromium 200 mcg/d
  • Placebo

Fig. 5.12: Nicotinamide in newly diagnosed type 1 diabetes. Meta-analysis of 10 randomized trials involving more than 200 newly diagnosed, nicotinamide-treated type 1 diabetic patients. One year after diagnosis baseline C-peptide (a measure of beta-cell function) was significantly higher in nicotinamide-treated pateints, compared with controls.

(Adapted from Pozzilli P, et al. Diabetes Care. 1996;19:1357)

HgbAlc (%) Fasting glucose Fasting insulin Total cholesterol mmol/l pmol/dl mmol/l

Values after 4 months of supplementation

Placebo 'Chromium 200 ^g/d Chromium 1 mg/d

HgbAlc (%) Fasting glucose Fasting insulin Total cholesterol mmol/l pmol/dl mmol/l

Values after 4 months of supplementation

Weakness, fatigue Faintness, dizziness Impaired concentration Headache Tachycardia Intense hunger Anxiety or panic attacks17 Cold sweats, nausea

Insomnia (if a meal is eaten late in the evening) Mood swings, personality changes

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