Evidence for Genetic Overlap between Type and Type Diabetes

Halki Diabetes Remedy

How To Reverse Diabetes Naturally

Get Instant Access

Even though, as described above, type 1 and type 2 diabetes represent two different disease entities, the clinical and etiological distinction between them is becoming more difficult as there is increasing evidence of a significant overlap between the two disease states. Clinical studies have reported that even within the same family both type 1 and type 2 diabetes may co-occur and patients with such double genetic predisposition have intermediate phenotype (259). As an example of common genetic predisposition, a variable number of tandem repeats polymorphism in the insulin gene promoter region has been associated with both type 1 and type 2 diabetes (259).

The "accelerator hypothesis" suggests that both type 1 and type 2 diabetes are the same disorder of insulin resistance set against different genetic background (260). According to this hypothesis, type 1 and type 2 diabetes are one and the same entity, distinguished only by the rate of P cell loss. Instead of overlap between the two types of diabetes, the hypothesis envisages overlay between the two types, with one disease representing a subset of the other.

Was this article helpful?

0 0
Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook


Post a comment