Contents

Series Preface vii

Preface xiii

Contributors xix

Part I Scope of the Problem

1 Nutrition and the Metabolic Syndrome: A Twenty-First-Century

Epidemic of Obesity and Eating Disorders 3

Christos S. Mantzoros

Part II Genetics and Pathophysiology

2 Genes and Gene-Environment Interactions in the Pathogenesis of Obesity and the Metabolic Syndrome 11

Despina Sanoudou, Elizabeth Vaiiadaki, and Christos S. Mantzoros

3 Environmental Inputs, Intake of Nutrients, and Endogenous

Molecules Contributing to the Regulation of Energy Homeostasis 41

Theodore Kelesidis, Iosif Kelesidis, and Christos S. Mantzoros

4 Central Integration of Environmental and Endogenous Signals Important in the Regulation of Food Intake and Energy Expenditure 77

IosifKelesidis, Theodore Kelesidis, and Christos S. Mantzoros

5 Insulin Resistance in States of Energy Excess:

Underlying Pathophysiological Concepts 107

Susann Bl├╝her and Christos S. Mantzoros

Part III Public Health Perspective

6 Targeting Childhood Obesity Through Lifestyle Modification 125

Eirini Bathrellou and Mary Yannakoulia

7 Diet and Physical Activity in the Prevention of Obesity 135

Frank B. Hu

8 Diet and Exercise in the Prevention and Management of the Metabolic Syndrome 149

Mary Yannakoulia, Evaggelia Fappa, Janice Jin Hwang, and Christos S. Mantzoros

9 Diet and Physical Activity in Cancer Prevention 161

Alicja Wolk

Part IV Nutrition Recommendations

10 Food Guide Pyramids and the 2005 MyPyramid 195

Jessica Fargnoli and Christos S. Mantzoros

11 Nutrition Recommendations for the General Population:

Where Is the Science? 209

Walter C. Willett and Meir J. Stampfer

12 Nutrition Recommendations and Interventions for

Subjects with Cardiovascular Disease 221

Meropi Kontogianni, Mary Yannakoulia, Lauren Kuhn, Sunali Shah, Kristina Day, and Christos S. Mantzoros

13 Medical Nutrition Therapy in the Treatment of

Type 1 and Type 2 Diabetes 245

Olga Kordonouri, Caroline Apovian, Lauren Kuhn, Thomas Danne, and Christos S. Mantzoros

Part V Clinical Assessment and Management

14 Mediterranean Diet in Disease Prevention: Current Perspectives 263

Jessica Fargnoli, Yoon Kim, and Christos S. Mantzoros

15 Lifestyle and Pharmacology Approaches for the

Treatment of Hypertension and Hyperlipidemia 279

Peter Oettgen

16 Diagnosis, Evaluation, and Medical Management of

Obesity and Diabetes 289

Jean L. Chan and Christos S. Mantzoros

17 Surgical Management of Obesity and Postoperative Care 329

George L. Blackburn, Torsten Olbers, Benjamin E. Schneider, Vivian M. Sanchez, Aoife Brennan, Christos S. Mantzoros, and Daniel B. Jones

18 Long-Term Impact of Weight Loss on Obesity and

Obesity-Associated Comorbidities 347

Janice Jin Hwang, George Blackburn, and Christos S. Mantzoros

Part VI Appendix

19 Methods for Classifying, Diagnosing, and Monitoring Obesity 371

Christos S. Mantzoros

20 Methods for Classifying, Diagnosing, and Monitoring Type II Diabetes 385

Christos S. Mantzoros

21 Major Nutrition Recommendations and Interventions for Subjects with Hyperlipidemia, Hypertension, and/or Diabetes 393

Christos S. Mantzoros

Part VII Resources

Resources 407

Index 415

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