Nutrition And Metabolism Book

Research on obesity spans a wide range of disciplines, from molecular biology to physiology to epidemiology and translational research to clinical medicine. This book attempts to review comprehensively, for practicing clinicians and scientists alike, our current understanding of how nutrition interacts with the genetic substrate as well as environmental-exogenous factors, including physical activity or the lack thereof, to result in insulin resistance and the metabolic syndrome. Furthermore,...

What Can We Recommend Today

Diet and exercise are the cornerstones of prevention and treatment of obesity and related disorders. Although dietary recommendations have been changing over the past few years, it is hoped that, as we learn more from both observational and interventional studies, our recommendations will continue to be refined and will hopefully prove to be more and more effective. It is also hoped that diagnostic and therapeutic methods will continue to improve significantly. New medications and new surgical...

Monogenic Obesity

Initial knowledge on the genetic involvement in monogenic obesity was derived from large-scale linkage analysis in obese mice carrying naturally occurring mutations. These analyses have pointed to disease-related loci and have identified the majority of gene mutations leading to monogenic obesity in mice 3 . In particular, the genetic characterization of naturally occurring obese animal models, such as ob ob, db db, fat and tubby mice, led to the discovery of recessive mutations in the genes...

Contributors

Caroline Apovian, MD Division of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA Eirini Bathrellou, MSc Department of Nutrition and Dietetics, Harokopio University, Athens, Greece George L. Blackburn, PhD, MD Division of Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Susann Bluher, MD Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany and Division of...