Placebo supplements Relative risk

intervention trial?____

Non-fatal myocardial infarction 4.23 1.35 0.32

Fatal myocardial infarction 1.35 1.74 1.29

All-cause mortality 2.69 3.48 1.29

Figure 7.2 suggests very strongly that a high plasma level of vitamin E is protective against coronary heart disease. Table 7.5 shows the results of the Cambridge Heart Anti-Oxidant Study.

Can you account for the discrepancy between the epidemiological study and the intervention trial?


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