Inhibition of carcinogen activation and

INCREASED CQNJUGATioN of ACTIVATED METABoLITES

Foreign compounds (and a number of endogenous metabolites, including steroid hormones) undergo two stages of metabolism before excretion:

  • Phase I metabolism is metabolic activation, leading to the introduction of reactive groups. Many such reactions involve hydroxylation catalysed by cytochromes of the P450 family.
  • Phase II metabolism is conjugation of these reactive groups with glucuronic acid, amino acids or sulphate to increase water solubility and permit urinary excretion.

Although phase I metabolism is considered to be catabolic, and part of the inactivation of steroid hormones, it also results in the production of active carcinogens from a number of otherwise inactive compounds.

A number of compounds present in fruits and vegetables either inhibit phase I metabolism or activate phase II metabolism, or both.

Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook


Post a comment