Role of Glutamine in the Pathogenesis of Type Diabetes

Since glutamine appears to act to promote lymphocyte activity, it has been proposed that increased availability of glutamine could play a role in the patho-genesis of some autoimmune conditions, such as type 1 diabetes (Wu et al., 1991). Indeed, the administration of the anti-glutamine-utilization drug acivicin delayed or stopped the progression of the disease in diabetes-prone rats (Misra et al., 1996). Addition of the glutaminase inhibitor 6-diazo-5-oxo-norleucine to macrophages before exposure to rat pancreatic p cells in vitro virtually abolished the lytic capacity of the macrophage towards the target p cells (Murphy and Newsholme, 1999). The glutamine concentration in the plasma of moderately ketoacidotic diabetics at diagnosis is significantly elevated compared with that of age- and sex-matched normal control individuals (P Newsholme, unpublished observations), adding further weight to the argument that this amino acid is important to the pathogenic process.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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