Albina, J.E., Henry, W., King, PA., Shearer, J., Mastrofrancesco, B., Goldstein, L. and Caldwell, M.D. (1987) Glutamine metabolism in rat skeletal muscle wounded with a-carrageenan. American Journal of Physiology 252, E49-E56. Ardawi, M.S.M. (1988a) Glutamine and glucose metabolism in human peripheral lymphocytes. Metabolism 37, 99-103. Ardawi, M.S.M. (1988b) Skeletal muscle glutamine metabolism in thermally-injured rats.

Clinical Science 74, 165-172. Ardawi, M.S.M. (1991) Effect of glutamine-enriched total parenteral nutrition on septic rats. Clinical Science 81, 215-222. Ardawi, M.S.M. and Newsholme, E.A. (1982) Maxiumum activities of some enzymes of glycolysis, the tricarboxylic acid cycle and ketone body and glutamine utilisation pathways in lymphocytes of the rat. Biochemical Journal 208, 743-748. Ardawi, M.S.M. and Newsholme, E.A. (1983) Glutamine metabolism in lymphocytes of the rat. Biochemical Journal 212, 835-842. Ardawi, M.S.M. and Newsholme, E.A. (1985) Metabolism in lymphocytes and its importance in the immune response. Essays in Biochemistry 21, 1-44. Ashworth, L.A.E. and MacLennan, A.P (1974) Comparison of L-asparaginases from Escherichia coli and Erwinia carotovora as immunosuppressants. Cancer Research 34, 1353-1359.

Askanazi, J., Elwyn, D.H., Kinney, J.M., Gump, FE., Michelsen, C.B., Stinchfield, FE., Furst, P, Vinnars, E. and Bergstrom, J. (1978) Muscle and plasma amino acids after injury: the role of inactivity. Annals of Surgery 188, 797-803. Askanazi, J., Carpentier, Y.A., Michelsen, C.B., Elwyn, D.H., Furst, P, Kantrowitz, L.R., Gump, FE. and Kinney, J.M. (1980) Muscle and plasma amino acids following injury: influence of intercurrent infection. Annals of Surgery 192, 78-85. Bergstrom, J., Furst, P, Noree, L.-O. and Vinnars, E. (1974) Intracellular free amino acid concentrations in human skeletal muscle tissue. Journal of Applied Physiology 36, 693-697.

Brambilla, G., Pardodi, S., Cavanna, M., Caraceni, C.E. and Baldini, L. (1970) The immunodepressive activity of E. coli L-asparaginase in some transplant systems. Cancer Research 30, 2665-2670. Brand, K. (1985) Glutamine and glucose metabolism during thymocyte proliferation.

Biochemical Journal 228, 353-361. Brand, K., Fekl, W., von Hintzenstern, J., Langer, K., Luppa, P and Schoerner, C.

(1989) Metabolism of glutamine in lymphocytes. Metabolism 38, 29-33. Burke, D.J., Alverdy, J.C., Aoys, E. and Moss, G.S. (1989) Glutamine-supplemented total parenteral nutrition improves gut immune function. Archives of Surgery 124, 1396-1399.

Calder, PC. (1994) Glutamine and the immune system. Clinical Nutrition 13, 2-8.

Calder, PC. (1995a) Fuel utilisation by cells of the immune system. Proceedings of the Nutrition Society 54, 65-82.

Calder, PC. (1995b) Requirement of both glutamine and arginine by proliferating lymphocytes. Proceedings of the Nutrition Society 54, 123A.

Calder, PC. and Newsholme, E.A. (1992) Glutamine promotes interleukin-2 production by concanavalin A-stimulated lymphocytes. Proceedings of the Nutrition Society 51, 105A.

Calder, PC. and Yaqoob, P (1999) Glutamine and the immune system. Amino Acids 17, 227-241.

Cao, Y., Feng, Z., Hoos, A. and Klimberg, VS. (1998) Glutamine enhances gut glutathione production. Journal of Parenteral and Enteral Nutrition 22, 224-227.

Castell, L.M., Poortmans, J.R., Leclercq, R., Brasseur, M., Duchateau, J. and Newsholme, E.A. (1997) Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. European Journal of Applied Physiology 75, 47-53.

Chakrabarti, R. (1998) Transcriptional regulation of the rat glutamine synthetase gene by tumor necrosis factor-alpha. European Journal of Biochemistry 254, 70-74.

Chakrabaty, A.K. and Friedman, H. (1970) L-asparaginase-induced immunosuppression: effects on antibody-forming cells and antibody titres. Science 167, 869-870.

Chang, W.K., Yang, K.D. and Shaio, M.F (1999a) Lymphocyte proliferation modulated by glutamine; involved in the redox reaction. Clinical and Experimental Immunology 117, 482-488.

Chang, W.K., Yang, K.D. and Shaio, M.F (1999b) Effect of glutamine on Th1 and Th2 cytokine responses of human peripheral blood mononuclear cells. Clinical Immunology 93, 294-301.

Chuang, J.C., Yu, C.L. and Wang, S.R. (1990) Modulation of human lymphocyte proliferation by amino acids. Clinical and Experimental Immunology 81, 173-176.

Crawford, J. and Cohen, H.J. (1985) The essential role of glutamine in lymphocyte differentiation in vitro. Journal of Cell Physiology 124, 275-282.

Curi, T.C.P, Demelo, M.P, Deazevedo, R.B., Zorn, T.M.T. and Curi, R. (1997) Glutamine utilization by rat neutrophils: presence of phosphate-dependent glutaminase. American Journal of Physiology 42, C1124-C1129.

Denno, R., Rounds, J.D., Faris, R., Holejko, L.B. and Wilmore, D.W. (1996) Glutamine-enriched total parenteral nutrition enhances plasma glutathione in the resting state. Journal of Surgical Research 61, 35-38.

Deutz, N.E.P, Reijven, PL.M., Athanasas, G. and Soeters, PB. (1992) Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs. Clinical Science 83, 607-614.

DeWitt, R.C., Wu, Y., Renegar, K.B. and Kudsk, K.A. (1999) Glutamine-enriched total parenteral nutrition preserves respiratory immunity and improves survival to Pseudomonas pneumonia. Journal of Surgical Research 84, 13-18.

Droge, W., Schulzeosthoff, K., Mihm, S., Galter, D., Schenk, H., Eck, H.P, Roth, S. and Gmunder, H. (1994) Functions of glutathione and glutathione disulfide immunology and immunopathology. FASEB Journal 8, 1131-1138.

Durden, D.L. and Distasio, J.A. (1981) Characterisation of the effects of asparaginase from Escherichia coli and a glutaminase-free asparaginase from Vibrio succino-genes on specific cell-mediated cytotoxicity. International Journal of Cancer 27, 59-65.

Eagle, H., Oyama, V.I., Levy, M., Horton, C.L. and Fleischman, R. (1956) The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid. Journal of Biological Chemistry 218, 607.

Ehrensvard, G., Fischer, A. and Stjernholm, R. (1949) Protein metabolism of tissue cells in vitro: the chemical nature of some obligate factors of tissue cell nutrition. Acta Physiologica Scandanavica 18, 218.

Elia, M. and Lunn, FIG. (1997) The use of glutamine in the treatment of gastrointestinal disorders in man. Nutrition 13, 743-747.

Furst, P, Bergstrom, J., Chao, L., Larsson, J., Liljedahl, S.-O., Neuhauser, M., Schildt, B. and Vinnars, E. (1979) Influence of amino acid supply on nitrogen and amino acid metabolism in severe trauma. Acta Chirurgica Scandinavica 494 (Suppl.), 136-138.

Furst, P, Pogan, K. and Stehle, P (1997) Glutamine dipeptides in clinical nutrition. Nutrition 13, 731-737.

Furukawa, S., Saito, H., Fukatsu, K., Hashiguchi, Y., Inaba, T., Lin, M., Inoue, T., Han, I., Matsuda, T. and Muto, T. (1997) Glutamine-enhanced bacterial killing by neutrophils from post-operative patients. Nutrition 13, 863-869.

Furukawa, S., Saito, H., Matsuda, T., Inoue, T., Fukatsu, K., Han, I., Ikeda, S., Hidemura, A. and Muto, T. (2000a) Relative effects of glucose and glutamine on reactive oxygen intermediate production by neutrophils. Shock 13, 274-278.

Furukawa, S., Saito, H., Inoue, T., Matsuda, T., Fukatsu, K., Han, I., Ikeda, S. and Hidemura, A. (2000b) Supplemental glutamine augments phagocytosis and reactive oxygen intermediate production by neutrophils and monocytes from postoperative patients in vitro. Nutrition 16, 323-329.

Garcia, C., Pithon Curi, T.C., De Lourdes Firmano, M., De Melo, M.P, Newsholme, P and Curi, R. (1999) Effect of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils. Clinical Science 96, 549-555.

Griffiths, M. and Keast, D. (1990) The effect of glutamine on murine splenic leucocyte responses to T and B-cell mitogens. Immunology and Cell Biology 68, 405-408.

Griffiths, R.D., Jones, C. and Palmer, T.E.A. (1997) Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition 13, 295-302.

Hack, V., Weiss, C., Friedmann, B., Suttner, S., Schykowski, M., Erbe, N., Benner, A., Bartsch, P and Droge, W. (1997) Decreased plasma glutamine level and CD4+ T-cell number in response to 8 wk of anaerobic training. American Journal of Physiology 272, E788-E795.

Hankard, R.G., Darmaun, D., Sager, B.K., Damore, D., Parsons, W.R. and Haymond, M. (1995) Response of glutamine metabolism to exogenous glutamine in humans. American Journal of Physiology 32, E663-E670.

Harward, T.R., Coe, D., Souba, W.W., Klingman, N. and Seeger, J.M. (1994) Glutamine preserves gut glutathione levels during intestinal ischemia/reperfusion. Journal of Surgical Research 56, 351-355.

Haussinger, D. (1989) Glutamine metabolism in the liver: overview and current concepts. Metabolism 38 (Suppl. 1), 14-17.

Heberer, M., Babst, R., Juretic, A., Gross, T., Horig, H., Harder, F and Spagnoli, G. (1996) Role of glutamine in the immune response in critical illness. Nutrition 12, S71-S72.

Hirsch, E.M. (1970) L-Glutaminase: suppression of lymphocyte blastogenic responses in vitro. Science 172, 736-738.

Hong, R.W., Rounds, J.D., Helton, W.S., Robinson, M.K. and Wilmore, D.W. (1992) Glutamine preserves liver glutathione after lethal hepatic injury. Annals of Surgery 215, 114-119.

Horvath, K., Jami, M., Hill, I.D., Papadimitriou, J.C., Magder, L.S. and Chanasongcram, S. (1996) Isocaloric glutamine-free diet and the morphology and function of rat small intestine. Journal of Parenteral and Enteral Nutrition 20, 128-134.

Houdijk, A.PJ., Rijnsburger, E.R., Jansen, J., Wesdorp, R.I.C., Weis, J.K., McCamish, M.A., Teerlink, T., Meuwissen, S.G.M., Haarman, H.J.T.M., Thijs, L.G. and van Leeuwen, PA.M. (1998) Randomised trial of glutamine-enriched parenteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 352, 772-776.

Inoue, Y., Grant, J.P and Snyder, PJ. (1993) Effect of glutamine-supplemented intravenous nutrition on survival after Escherichia coli-induced peritonitis. Journal of Parenteral and Enteral Nutrition 17, 41-46.

Jensen, G.L., Miller, R.H., Talabiska, D.G., Fish, J. and Gianferante, L. (1996) A double blind, prospective, randomized study of glutamine-enriched compared with standard peptide-based feeding in critically ill patients. American Journal of Clinical Nutrition 64, 615-621.

Kafkewitz, D. and Bendich, A. (1983) Enzyme-induced asparagine and glutamine depletion and immune system dysfunction. American Journal of Clinical Nutrition 37, 1025-1030.

Keast, D. and Newsholme, E.A. (1990) Effect of mitogens on the maximum activities of hexokinase, lactate dehydrogenase, citrate synthase and glutaminase in rat mesen-teric lymph node lymphocytes and splenocytes during the early period of culture. International Journal of Biochemistry 22, 133-136.

Keast, D., Arstein, D.L., Harper, W., Fry, R.W. and Morton, A.R. (1995) Depression of plasma glutamine concentration after exercise stress and its possible influence on the immune system. Medical Journal of Australia 162, 15-18.

Kew, S., Wells, S.M., Yaqoob, P, Wallace, FA., Miles, E.A. and Calder, PC. (1999) Dietary glutamine enhances murine T-lymphocyte responsiveness. Journal of Nutrition 129, 1524-1531.

Kinscherf, R., Fischbach, T., Mihm, S., Roth, S., Hohenhaus-Sievert, E., Weiss, C., Edler, L., Bartsch, P. and Droge, W. (1994) Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells. FASEB Journal 8, 448-451.

Kohler, H., Hartig-Knecht, H., Ruggeberg, J., Adam, R. and Schroten, H. (2000) Lymphocyte proliferation is possible with low concentrations of glycyl-glutamine. European Journal of Nutrition 39, 103-105.

Kudsk, K.A., Wu, Y., Fukatsu, K., Zarzaur, B.L., Johnson, C.D., Wang, R. and Hanna, M.K. (2000) Glutamine-enriched total parenteral nutrition maintains intestinal inter-leukin-4 and mucosal immunoglobulin A levels. Journal of Parenteral and Enteral Nutrition 24, 270-274.

Kweon, M.N., Moriguchi, S., Mukai, K. and Kishino, Y. (1991) Effect of alanylglutamine-enriched infusion on tumour growth and cellular immune function in rats. Amino Acids 1, 7-16.

Lacey, J.M. and Wilmore, D.W. (1990) Is glutamine a conditionally essential amino acid? Nutrition Reviews 48, 297-309.

Li, J., Kudsk, K.A., Janu, P and Renegar, K.B. (1997) Effect of glutamine-enriched TPN on small intestine gut-associated lymphoid tissue (GALT) and upper respiratory tract immunity. Surgery 121, 542-549.

Li, J., King, B.K., Janu, PG., Renegar, K.B. and Kudsk, K.A. (1998) Glycyl-L-glutamine-enriched total parenteral nutrition maintains small intestine gut-associated lym-phoid tissue and upper respiratory tract immunity. Journal of Parenteral and Enteral Nutrition 22, 31-36.

Lund, J., Stjernstrom, H., Bergholm, U., Jorfeldt, L., Vinnars, E. and Wiklund, L. (1986) The exchange of blood-borne amino acids in the leg during abdominal surgical trauma: effects of glucose infusion. Clinical Science 71, 487-496.

Lund, Fl (1981) Metabolism of glutamine, glutamate and aspartate. In: Waterlow, J.C. and Stephen, J.M.L. (eds) Nitrogen Metabolism in Man. Applied Sciences, London, pp. 155-167.

Lund, P and Williamson, D.H. (1985) Inter-tissue nitrogen fluxes. British Medical Bulletin 41, 251-256.

Manhart, N., Vierlinger, K., Akomeah, R., Bergmeister, H., Spittler, A. and Roth, E. (2000) Influence of enteral diets supplemented with key nutrients on lymphocyte subpopulations in Peyer's patches of endotoxin-boostered mice. Clinical Nutrition 19, 265-269.

Max, S.R., Hill, J., Mearow, K., Konagaya, H., Konagaya, Y., Thomas, J.W., Banner, C. and Vitkavic, L. (1988) Dexamethasone regulates glutamine synthetase expression in rat skeletal muscles. American Journal of Physiology 255, E397-E403.

Milewski, PJ., Threlfall, C.J., Heath, D.F, Holbrook, J.B., Wilford, K. and Irving, M.H. (1982) Intracellular free amino acids in undernourished patients with and without sepsis. Clinical Science 62, 83-91.

Misra, M., Duguid, W.P and Marliss, E.B. (1996) Prevention of diabetes in the spontaneously diabetic BB rat by the glutamine antimetabolite acivicin. Canadian Journal of Physiology and Pharmacology 74, 163-172.

Morlion, B.J., Stehle, P, Wachter, P, Siedhoff, H.P, Koller, M., Konig, W., Furst, P and Puchstein, C. (1998) Total parenteral nutrition with glutamine dipeptide after major abdominal surgery - a randomized, double-blind, controlled study. Annals of Surgery 227, 302-308.

Muhlbacher, FF, Kapadia, C.R., Colpoys, M.F, Smith, R.J. and Wilmore, D.W. (1984) Effects of glucocorticoids on glutamine metabolism in skeletal muscle. American Journal of Physiology 247, E75-E83.

Murphy, C.J. and Newsholme, P (1998) The importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production. Clinical Science 95, 397-407.

Murphy, C. and Newsholme, P (1999) Macrophage-mediated lysis of a ß-cell line, tumour necrosis factor-a release from bacillus Calmette-Guerin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism. Clinical Science 96, 89-97.

Naka, S., Saito, H., Hashiguchi, Y., Lin, M.T., Furukawa, S., Inoba, T., Fukushima, R., Wada, N. and Muto, T. (1996) Alanyl-glutamine-supplemented total parenteral nutrition improves survival and protein metabolism in rat protracted bacterial peritonitis model. Journal of Parenteral and Enteral Nutrition 20, 417-423.

Neu, J., Roig, J.C., Meetze, W.H., Veerman, M., Carter, C., Millsaps, M., Bowling, D., Dallas, M.J., Sleasman, J., Knight, T. and Anestad, N. (1997) Enteral glutamine supplementation for very low birthweight infants decreases morbidity. Journal of Pediatrics 131, 691-699.

Newsholme, E.A. and Calder, PC. (1997) The proposed role of glutamine in some cells of the immune system and speculative consequences for the whole animal. Nutrition 13, 728-730.

Newsholme, E.A., Newsholme, P, Curi, R., Crabtree, B. and Ardawi, M.S.M. (1989) Glutamine metabolism in different tissues: its physiological and pathological importance. In: Kinney, J.M. and Borum, PR. (eds) Perspectives in Clinical Nutrition. Urban and Schwarzenberg, Baltimore, pp. 71-98.

Newsholme, P (1987) Studies on metabolism in macrophages. D Phil thesis, University of Oxford.

Newsholme, P (2001) Why is L-glutamine metabolism important to cells of the immune system in health, post-injury, surgery or infection? Journal of Nutrition 131, 2515S-2522S.

Newsholme, P and Newsholme, E.A. (1989) Rates of utilisation of glucose, glutamine and oleate and formation of end products by mouse peritoneal macrophages in culture. Biochemical Journal 261, 211-218.

Newsholme, P, Curi, R., Gordon, S. and Newsholme, E.A. (1986) Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochemical Journal 239, 121-125.

Newsholme, P, Gordon, S. and Newsholme, E.A. (1987) Rates of utilisation and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages. Biochemical Journal 242, 631-636.

Newsholme, P, Costa Rosa, L.FB.P, Newsholme, E.A. and Curi, R. (1996). The importance of macrophage fuel metabolism to its function. Cell Biochemistry and Function 14, 1-10.

Newsholme, P, Curi, R., Curi, T.C.P, Murphy, C.J., Garcia, C. and de Melo, M.P (1999) Glutamine metabolism by lymphocytes, macrophages and neutrophils: its importance in health and disease. Journal of Nutritional Biochemistry 10, 316-324.

Ogle, C.K., Ogle, J.D., Mao, J.X., Simon, J., Noel, J.G., Li, B.G. and Alexander, J.W. (1994) Effect of glutamine on phagocytosis and bacterial killing by normal and pediatric burn patient neutrophils. Journal of Parenteral and Enteral Nutrition 18, 128-133.

O'Riordain, M., Fearon, K.C., Ross, J.A., Rogers, P, Falconer, J.S., Bartolo, D.C.C., Garden, O.J. and Carter, D.C. (1994) Glutamine supplemented parenteral nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal resection. Annals of Surgery 220, 212-221.

O'Rourke, A.M. and Rider, L.C. (1989) Glucose, glutamine and ketone body utilisation by resting and concanavalin A activated rat splenic lymphocytes. Biochimica et Biophysica Acta 1010, 342-345.

Oudemans-van Straaten, H.M., Bosman, R.J., Treskes, M., van der Spoel, H.J.I. and Zandstra, D.F (2001) Plasma glutamine depletion and patient outcome in acute ICU admissions. Intensive Care Medicine 27, 84-90.

Parry-Billings, M., Leighton, B., Dimitriadis, G.D., de Vasconcelos, PR.L. and Newsholme, E.A. (1989) Skeletal muscle glutamine metabolism during sepsis. International Journal of Biochemistry 21, 419-423.

Parry-Billings, M., Evans, J., Calder, P.C. and Newsholme, E.A. (1990a) Does glutamine contribute to immunosuppression after major burns? Lancet 336, 523-525.

Parry-Billings, M., Leighton, B., Dimitriadis, G.D., Bond, J. and Newsholme, E.A. (1990b) Effects of physiological and pathological levels of glucocorticoids on skeletal muscle glutamine metabolism in the rat. Biochemical Pharmacology 40, 1145-1148.

Parry-Billings, M., Leighton, B., Dimitriadis, G., Curi, R., Bond, J., Bevan, S., Colquhoun, A. and Newsholme, E.A. (1991) The effect of tumour bearing on skleletal muscle glutamine metabolism. International Journal of Biochemistry 23, 933-937.

Parry-Billings, M., Baigrie, R.J., Lamont, P.M., Morris, P.J. and Newsholme, E.A. (1992a) Effects of major and minor surgery on plasma glutamine and cytokine levels. Archives of Surgery 127, 1237-1240.

Parry-Billings, M., Budgett, R., Koutedakis, Y., Blomstrand, E., Williams, C., Calder, P.C., Pilling, S., Baigrie, R. and Newsholme, E.A. (1992b) Plasma amino acid concentrations in the overtraining syndrome: possible effects on the immune system. Medicine and Science in Sports and Exercise 24, 1353-1358.

Peltonen, E., Pulkki, K. and Kirvela, O. (1997) Stimulatory effect of glutamine on human monocyte activation as measured by interleukin-6 and soluble interleukin-6 receptor release. Clinical Nutrition 16, 125-128.

Peterson, J.D., Herzenberg, L.A., Vasquez, K. and Waltenbaugh, C. (1998) Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proceedings of the National Academy of Sciences of the USA 95, 3071-3076.

Powell, H., Castell, L.M., Parry-Billings, M., Desborough, J.P, Hall, G.M. and Newsholme, E.A. (1994) Growth hormone suppression and glutamine flux associated with cardiac surgery. Clinical Physiology 14, 569-580.

Rohde, T., Maclean, D.A. and Pedersen, B.K. (1996a) Glutamine, lymphocyte proliferation and cytokine production. Scandinavian Journal of Immunology 44, 648-650.

Rohde, T., Maclean, D.A., Hartkopp, A. and Pedersen, B.K. (1996b) The immune system and serum glutamine during a triathlon. European Journal of Applied Physiology 74, 428-434.

Roth, E., Funovics, J., Muhlbacher, F, Schemper, M., Mauritz, W., Sporn, P and Fritsch, A. (1982) Metabolic disorders in severe abdominal sepsis: glutamine deficiency in skeletal muscle. Clinical Nutrition 1, 25-41.

Saito, H., Furukawa, S. and Matsuda, T. (1999) Glutamine as an immunoenhancing nutrient. Journal of Parenteral and Enteral Nutrition 23 (Suppl.), S59.

Schroder, J., Lahlke, V, Fandrich, F, Gebhardt, H., Erichsen, H., Zabel, P and Schroeder, P. (1998) Glutamine dipeptides-supplemented parenteral nutrition reverses gut muscosal structure and interleukin-6 release of rat intestinal mononu-clear cells after hemorrhagic shock. Shock 10, 26-31.

Shewchuk, L.D., Baracos, VE. and Field, C.J. (1997) Dietary L-glutamine supplementation reduces growth of the Morris Hepatoma 7777 in exercise-trained and sedentary rats. Journal of Nutrition 127, 158-166.

Simberkoff, M.S. and Thomas, L. (1970) Reversal by L-glutamine of the inhibition of lymphocyte mitosis caused by E. coli asparaginase. Proceedings of the Society of Experimental Biology 133, 642-643.

Souba, W.W. (1991) Glutamine: a key substrate for the splanchnic bed. Annual Review in Nutrition 11, 285-308.

Spittler, A., Winkler, S., Gotzinger, P, Oehler, R., Willheim, M., Tempfer, C., Weigel, G., Fugger, R., Boltz-Nitulescu, G. and Roth, E. (1995) Influence of glutamine on the phenotype and function of human monocytes. Blood 86, 1564-1569.

Spittler, A., Holzer, S., Oehler, R., Boltz-Nitulescu, G. and Roth, E. (1997) A glutamine deficiency impairs the function of cultured human monocytes. Clinical Nutrition 16, 97-99.

Spittler, A., Sautner, T., Gornikiewicz, A., Manhart, N., Oehler, R., Bergmann, M., Fugger, R. and Roth, E. (2001) Postoperative glycyl-glutamine infusion reduces immunosuppression: partial prevention of the surgery induced decrease in HLA-DR expression on monocytes. Clinical Nutrition 20, 37-42.

Spolarics, Z., Lang, C.H., Bagby, G.J. and Spitzer, J.J. (1991) Glutamine and fatty acid oxidation are the main sources of energy in Kupffer and endothelial cells. American Journal of Physiology 261, G185-G190.

Stinnett, J.D., Alexander, J.W., Watanabe, C., Elwyn, D.H., Furst, P, Kantrowitz, L.R., Gump, FE. and Kinney, J.M. (1982) Plasma and skeletal muscle amino acids following severe burn injury in patients and experimental animals. Annals of Surgery 195, 75-89.

Suh, Y.A., Arnold, R.S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A.B., Griendling, K.K. and Lambeth, D. (1999) Cell transformation by the superoxidegenerating oxidase Mox 1. Nature 401, 79-82.

Suzuki, I., Matsumoto, Y., Adjei, A.A., Osato, L., Shinjo, S. and Yamamoto, S. (1993) Effect of a glutamine-supplemented diet in response to methicillin-resistant Staphylococcus aureus infection in mice. Journal of Nutritional Science and Vitaminology 39, 405-410.

Szondy, Z. and Newsholme, E.A. (1989) The effect of glutamine concentration on the activity of carbamoyl-phosphate synthase II and on the incorporation of [3H]thymi-dine into DNA in rat mesenteric lymphocytes stimulated by phytohaemagglutinin. Biochemical Journal 261, 979-983.

Tizianello, A., Deferrari, G., Garibotto, G., Robabaudo, C., Asquarone, N. and Ghiggeri, G.N. (1982) Renal ammoniagenesis in an early stage of metabolic acidosis in man. Journal of Clinical Investigation 69, 240-250.

van der Hulst, R.R.W., van Kreel, B.K., von Meyenfeldt, M.F, Brummer, R.-J.M., Arends, J.-W., Deutz, N.E.P and Soeters, FIB. (1993) Glutamine and the preservation of gut integrity. Lancet 341, 1363-1365.

Wallace, C. and Keast, D. (1992) Glutamine and macrophage function. Metabolism 41, 1016-1020.

Welbourne, T.C. and Dass, PD. (1982) Function of renal 7-glutamyl-transferase: significance of glutathione and glutamine. Life Sciences 30, 793-801.

Welbourne, T.C., King, A.B. and Horton, K. (1993) Enteral glutamine supports hepatic glutathione efflux during inflammation. Journal of Nutritional Biochemistry 4, 236-242.

Wells, S.M., Kew, S., Yaqoob, P, Wallace, FA. and Calder, PC. (1999) Dietary gluta-mine enhances cytokine production by murine macrophages. Nutrition 15, 881-884.

Wilmore, D. and Shabert, J.K. (1998) Role of glutamine in immunologic responses. Nutrition 14, 618-626.

Windmueller, H.G. and Spaeth, A.E. (1974) Uptake and metabolism of plasma gluta-mine by the small intestine. Journal of Biological Chemistry 249, 5070-5079.

Wu, G., Field, C.J. and Marliss, E.B. (1991) Elevated glutamine metabolism in spleno-cytes from spontaneously diabetic BB rats. Biochemical Journal 274, 49-54

Yaqoob, P and Calder, PC. (1997) Glutamine requirement of proliferating T lymphocytes. Nutrition 13, 646-651.

Yaqoob, P and Calder, PC. (1998) Cytokine production by human peripheral blood mononuclear cells: differential sensitivity to glutamine availability. Cytokine 10, 790-794.

Yassad, A., Husson, A., Bion, A. and Lavoinne, A. (2000) Synthesis of interleukin 1 beta and interleukin 6 by stimulated rat peritoneal macrophages: modulation by glutamine. Cytokine 12, 1288-1291.

Yoo, S.S., Field, C.J. and McBurney, M.I. (1997) Glutamine supplementation maintains intramuscular glutamine concentrations and normalizes lymphocyte function in infected early weaned pigs. Journal of Nutrition 127, 2253-2259.

Yoshida, S., Hikida, S., Tanaka, Y., Yanase, A., Mizote, H. and Kaegawa, T. (1992) Effect of glutamine supplementation on lymphocyte function in septic rats. Journal of Parenteral and Enteral Nutrition 16, 30S.

Yoshida, S., Matsui, M., Shirouzu, Y., Fujita, H., Yamana, H. and Shirouzu, K. (1998) Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer. Annals of Surgery 227, 485-491.

Ziegler, T.R., Young, L.S., Benfell, K., Scheltinga, M., Hortog, K., Bye, R., Morrow, FD., Jacobs, D.O., Smith, R.J., Antin, J.H. and Wilmore, D.W. (1992) Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition following bone marrow transplantation: a double-blinded, randomized, controlled trial. Annals of Internal Medicine 116, 821-828.

Ziegler, T.R., Bye, R.L., Persinger, R.L., Young, L.S., Antin, J.H. and Wilmore, D.W. (1998) Effects of glutamine supplementation on circulating lymphocytes after bone marrow transplantation: a pilot study. American Journal of Medical Science 315, 4-10.

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