Influence of glutamine on neutrophil functions in vitro

Addition of glutamine to cultures of blood neutrophils taken from patients with burns or post-surgery improved the defective anti-microbial activities (e.g. decreased reactive oxygen species production, phagocytosis and bactericidal activity) of those cells (Ogle et al., 1994; Furukawa et al., 1997, 2000a, b). A study by Garcia et al. (1999) suggests a mechanism by which glutamine may promote increased antimicrobial activity by neutrophils in stress states: 2 mM extracellular glutamine was able to attenuate the adrenaline-induced inhibition of superoxide production in these cells, suggesting that glutamine may protect cells from the suppressive effects of stress hormones.

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