Influence of glutamine on B lymphocyte differentiation in vitro

The differentiation of B lymphocytes into antibody-synthesizing cells in vitro is glutamine-dependent and increases greatly over the physiological range of glut-amine concentrations (Crawford and Cohen, 1985). This effect of glutamine cannot be mimicked by glutamate or asparagine.

Physiological concentration range

Physiological concentration range

Glutamine in culture medium (mM)

Fig. 6.5. Effect of glutamine on human blood lymphocyte proliferation in vitro. dpm, disintegrations per minute. P.C. Calder data are previously unpublished.

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