Effector mechanisms of Thmediated immunity

Th2-biased immune responses are believed to be important in the immune responses against helminth infections. If, however, Th2-biased immune responses are inappropriately directed against innocuous antigens, such as allergens, tissue damage and inflammation may ensue. These inappropriate Th2 responses underlie asthma, eczema, hay fever and some food allergies.

Th2 cytokines induce the isotype switching of B-cells to the synthesis of IgE. They also promote the growth, differentiation and release of mast cells and eosinophils from the bone marrow. Eosinophils are directed towards sites of helminth infection and allergy by chemokines, such as eotaxin, which are released by Th-cells. Th2 cytokines also activate eosinophils. In a situation analogous to Th1-biased responses, Th2-biased Th-cells induce a package of biological responses that are characteristic of allergy and helminth infection, namely, high levels of circulating IgE, mastocytosis and tissue eosinophilia.

Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook


Post a comment