Conclusion

The favourable modulatory effects of arginine in the immune system have been well documented in animal models and some have been reproduced in humans. The most prominent effect of supplemental arginine is in abrogating trauma-induced immunosuppression - in particular, the reductions seen in T-cell mitogenesis, delayed-type hypersensitivity response, macrophage and natural killer cell cytotoxicity and the improvement of wound healing. In the clinical setting, immunonutrition, comprising supplemental arginine, nucleic acids and n-3 fatty acids, has been demonstrated to reduce infectious complications (e.g. see Table 5.2) and length of hospital stay in critically ill patients.

Table 5.2. The incidence of septic complications in prospective randomized trials comparing arginine-supplemented patients with non-supplemented controls.

Infectious complications

Table 5.2. The incidence of septic complications in prospective randomized trials comparing arginine-supplemented patients with non-supplemented controls.

Infectious complications

Patient cohort

Author

N

Experimental diet

Experimental

Control

Cancer surgery

Daly et al. (1992)

85

IMPACT®

11a

37

Cancer surgery

Daly et al. (l995)

60

IMPACT®

10a

43

Cancer surgery

Braga et al. (1998)

60

IMPACT®

10

15

Cancer surgery

Senkal et al. (1999)

164

IMPACT®

18a

35

Trauma

Brown et al. (1994)

37

IMPACT®

16a

56

Trauma

Kudsk et al. (1996)

33

Immun-Aid®

6a

41

Trauma

Moore et al. (1994)

98

Immun-Aid®

0a

11

Mixed ICU

Bower et al. (1995)

296

IMPACT®

6b

13

Mixed ICU

Galban et al. (2000)

181

IMPACT®

8a,b

22

bBacteraemia.

ICU, intensive care unit.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment