Amount of fat in the diet and innate immune function

Several studies have compared the effects of feeding laboratory animals low-and high-fat diets on innate immune responses, such as natural killer cell activity. Most studies have found that high-fat diets result in diminished innate immune responses (for references, see Calder, 1998a), but the precise effect depends upon the exact level of fat used in the high-fat diet and its source. Human natural killer cell activity was significantly increased by a reduction in fat intake to less than 30% of energy (Barone et al., 1989; Hebert et al., 1990).

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