Amount of fat in the diet and acquired immune function

A number of studies have compared the effects of feeding laboratory animals low- and high-fat diets (usually high in saturated fat) upon lymphocytes. These studies have concluded that high-fat diets are associated with suppressed T-cell proliferation (for references, see Calder, 1998a). This conclusion is supported by studies in humans that showed significantly enhanced lymphocyte proliferation in response to mitogens if healthy subjects were fed a diet where fat contributed 25% of energy (Kelley et al., 1989, 1992).

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