Smooth muscle cell proliferation

through stimulation of guanylate cyclase.

These three factors—leukocyte adhesion, proliferation, and subsequent platelet aggregation—are of great significance in the initial phase of arteriosclerosis. The weakening of the Arg-NO system seems a likely pathogenetic factor in vascular lesions. Several variables are discussed as triggering factors for defects in NOS activity (C): reduced receptor coupling of the agonists, marginal substrate (Arg) or cofactor availability, or inactivation of EDRF (NO) on its way to the site of its intended activity. The latter is blamed mainly on oxidized LDL and/or peroxide anions. In arteriosclerotic vessels, an abnormal vasoconstrictor (endothelin 1) might also form, compensating for the relaxing effect of NO.

Regulatory Functions I

A. NO Synthesis

Shearing forces-

Bradykinin^ Acetylcholine



Bradykinin^ Acetylcholine

Lipoprotein Transport Distribution
C. Interfering Factors -

L-Arginine cofactors




^.Guanylate cyclase


Smooth musculature

My Life My Diet

My Life My Diet

I lost over 60 pounds and 4+ inches off my waist without pills, strenuous exercise, or any of the things that the diet experts tell you to do...and I did it in less than 4 months! If you have the desire, and can read through my e-book , then this is for you! I could have easily made it a lot more difficult, with stacks of information that people will never read, but why?

Get My Free Ebook

Post a comment