In 1994, three cases of neonatal severe diarrhea with abnormal epithelial pictures were reported by Reifen et al under the name of 'tufting enteropa thy'.36 In our own series at Necker-Enfants Malades, we identified nine cases of severe neonatal diarrhea that were clearly different from MVID.12 Further studies in these patients confirmed that intestinal epithelial dysplasia (IED) is a constitutive epithelial disorder involving both small intestine and colon.37 In our experience, IED seems to be frequent in patients of Arabic origin, from the Middle-East or North Africa. Main characteristics of this disease are its clinical and histo-logical heterogeneity and its association with malformations or other epithelial diseases.
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