Intersection of the nutrition science and clinical axes defining the response phenotype

Only three of the 51 studies summarized in the AHRQ review reported any attempt to genotype the subjects for any polymorphisms known to be involved in cholesterol metabolism (these three studies identified subjects with familial hypercholesterolemia). Two of the 51 studies investigated soy protein efficacy in type II diabetic subjects. The criteria for study subject selection in the rest of the 51 studies were fairly broad and included men and pre- and post-menopausal women of various ages and...

References

Balk, E., Chung, M., Chew, P. et al. (2005). Effects of soy on health outcomes. AHRQ Publication No. 05-E024-2. Rockville, MD Agency for Healthcare Research and Quality. Balk, E.M., Horsley, T.A. and Newberry, S.J. (2007). A collaborative effort to apply the evidence-based review process to the field of nutrition challenges benefits, and lessons learned. Am J Clin Nutr 85 1448-56. Baum, J.A., Teng, H., Erdman, J.W. Jr., et al. (1998). Long-term intake of soy protein improves blood lipid...

The future for the business of nutrigenomics

What does the future hold With advances in science, better understanding from various regulatory authorities all over the world and with a concerted effort from stakeholders from industry, interested consumer groups and governmental representatives, the future seems filled with possibilities for the development of successful business models in nutrigenomics. Beyond the corporate bottom line, nutrigenomics can make significant improvements to the health and well-being of the consumer. What might...

Types of dtc genetic tests on the market

A growing number of commercial firms are advertising and selling genetic tests directly to consumers. A February 2008 article in Nature Biotechnology observes The onset of genetic testing as a wide-spread consumer commodity continues to gather pace. At least 27 web-based companies now offer genetic tests - once the exclusive domain of hospital clinics and academic laboratories - directly to consumers for costs ranging from roughly 100 for a simple gene scan to 350000 for a personal genome...

Laboratorydeveloped tests and medical device regulations

Genetic testing is characterized by a high degree of dependence on laboratory-developed tests (LDTs). In the European Union, Sweden and Australia, LDTs are included in the device regulations (although there are exemptions in the EU system for laboratories based within health institutions). In Canada, device regulators have sought legal opinion on whether they can regulate LDTs and have received a succession of conflicting opinions. Recently, they have stated that the development and use of an...

Contents

Acknowledgments ix Editors' Introduction xi 1. Gene-Environment Interactions Where are we and where should 2. Translating Nutrigenomics Research into Practice The Example 3. Business Applications of Nutrigenomics An Industry Perspective 45 4. Regulation of Genetic Tests An International Comparison 63 5. Risk-Based Regulation of Direct-to-Consumer Nutrigenetic 6. The Impact of Genomics on Innovation in Foods and Drugs Can Canadian Law Step Up to the Challenge 103 7. Placing Healthy Eating in the...

Translating Nutrigenomics Research into Practice The Example of Soy Protein

Soy Protein as a Cholesterol-Lowering Nutrient 28 Soy Proteins as Products by Process 29 Processing and Biochemical Characterization of Soy Proteins 32 The Proposed Minimum Information About a Dietary Protein MIADP Characterized Soy Proteins Enables Mechanism of Action Research 36 Intersection of the Nutrition Science and Clinical Axes Defining the Nutrition and Genomics ISBN 978-0-12-374125-7

Gene Diet Interactions

Most of the emphasis on gene-environment interactions continues to be placed on gene-diet interactions. Unlike studies focusing on tobacco smoking, alcohol and physical activity, studies of gene-diet interactions include both observational and intervention studies. The major concern with extracting information about dietary intake from observational studies continues to be the use of dietary intake assessments that do not accurately reflect true intake of the individual. Improvements in data...

Luna Tsujita Fotolog

Andreasen, C.H., Stender-Petersen, K.L., Mogensen, M.S., et al. 2008 . Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 57 95-101. Arkadianos, I., Valdes, A.M., Marinos, E., Florou, A., Gill, R.D. and Grimaldi, K.A. 2007 . Improved weight management using genetic information to personalize a calorie controlled diet. Nutr J 6 29. Baylin, A. and Campos, H. 2006 . The use of fatty acid biomarkers to reflect dietary intake. Curr Opin...