EDTA Therapy for Vascular Disease

Chelation Natural Miracle For Protecting Your Heart

Chelation therapy has been conclusively shown to be up to 82 Percent Effective at dissolving the plaque that blocks arteries! In the ebook Chelation Natural Miracle For Protecting Your Heart you'll discover: The frustrating reason many doctors are ignoring Edta chelationor even openly rejecting it. The deadly heart surgeries even the American Heart Association admits are unnecessary. The hidden signs and symptoms of heart attacks and strokes? Are you in danger right now?. The average number of years stripped away by heart and vessel disease. Can you get them back?. The newest set of risk factors for heart disease (they'll likely surprise you!). Shady government practices that protect Big Pharma and keep Edta chelation out of the public eye. How the Roman Empire could have been savedif only they'd known about Edta chelation. Why Edta chelation is guaranteed to be safeeven in extremely high doses. (It puts aspirin to shame!). The shocking truth about plaque in young childrenand how to keep your little ones safer. Why dentists, artists and welders need Edta chelationand whether your workplace is dangerous too. The differences between IV and oral chelationand which kind of Edta is right for you. Other forms of chelationand how these little-known treatments can dramatically boost your health.

Chelation Natural Miracle For Protecting Your Heart Summary

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Author: Michael Cutler, M.D.
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Monitoring During Therapy

The need for evaluation of kidney function before instituting DMSA therapy is not absolute. Elderly persons, especially those with obvious health problems, should have a renal-function evaluation done. This can be done by ordering a BUN and creatinine study (blood test) before beginning chelation. Persons with known kidney disease should have DMSA administered only by a medical practitioner knowledgeable in the use of DMSA or other chelating drugs. One problem I see frequently among those who administer chelation therapy, even among well-known practitioners, is a failure to do follow-up studies on heavy metal levels, as well as levels of trace minerals. This is especially important when using EDTA, since it can chelate numerous necessary metals, in addition to the harmful ones.

Dr Christopher Calpai

Treating the condition is done via looking at a blood test for vitamins and minerals, looking to see what the person's diet consists of, what they do for work, where they work, what they're exposed to at work, their home environment, doing a 24-hour urine test with an intravenous chelation procedure, and testing for creatinine clearance (kidney function), as well as testing for heavy metals. The latest and best treatment is a combination of oral vitamins and minerals to maximize immune function, exercise, and intravenous EDTA chelation therapy to remove the metals. Vitamin C is also beneficial. Some people use intravenous vitamin C and alternate that with chelation. Chelation therapy is a treatment that has been around for many years. It involves using an intravenous application or induction of a protein substance that helps to bind heavy metals, to drag them and throw them out of the body through the urine. It takes about three hours to do. It also has been shown to produce...

Treating Mercury Toxicity

If your mercury is still elevated, repeat two more cycles, followed by a repeat in the toxic screen test. Continue this until your mercury levels are undetectable. Some suggest that chelation must be continued for several months or even a year in cases of obvious neurological problems. Instead, I recommend taking garlic extract at a dose of 600 mg three times a day for at least one year. You can take it permanently without experiencing any side effects. Garlic is also excellent for reducing atherosclerosis.

Mercury Exposure in Adulthood

Mercury's effects on the endocrine system can be significant, especially in cases of chronic exposure. The above study also found that women experiencing primary miscarriages (the first of a series of miscarriages) had lower progesterone levels, and higher mercury levels, following provocative chelation tests for mercury. Other studies have shown that mercury directly inhibits progesterone production in the ovary's granulosa cells, and has a profound effect on estradiol as well. Women with both primary and secondary miscarriages had higher mercury levels than did women who had never had miscarriages. Another study found that the incidence of luteal insufficiency (low progesterone) was significantly increased in women with ten or more amalgam fillings.63

Mechanisms of copper absorption

Copper uptake by the intestinal mucosa is strongly influenced by chelation of copper ions by amino acids. Chelation may even be a mandatory requirement for copper absorption.64 Yet, although dietary amino acids can enhance copper absorption, when present in excess they may result in copper malabsorption, possibly by competing with binding proteins on the enterocyte membrane. The ratio of chelate to metal may determine whether there is a net inhibition or promotion of copper uptake. In one human study, methionine supplementation was found to increase copper absorption.72 Animal studies have provided less straightforward results. One study of rats found that excess dietary methionine decreased indices of copper status.73 Jejunal copper uptake has been found to be decreased by high levels of dietary proline or histidine,74 while excessive cystine and cysteine have been shown to exacerbate the effects of dietary copper deficiency.75 Cysteine is thought to decrease copper bioavailability...

Behavioral and Neurological Effects of Mercury Exposure During Childhood

One report of two adolescents, aged thirteen and fifteen, who were unintentionally exposed to high levels of mercury vapor for three months, found that both suffered from a diffuse encephalopathy (brain dysfunction).57 When examined a year later, they had improved on psychiatric testing but continued to have defects in visual perception, construction skills, nonverbal memory, and conceptual abstractions. These symptoms persisted despite the removal of the mercury from the blood by chelation, demonstrating that actual destruction of widespread parts of the brain can occur, and that even during adolescence, the brain is more sensitive than an adult's.

Mercury in Vaccines a Brainless Idea From the Very Beginning

One problem in treating children, as well as adults, is that often we find either low or even undetectable levels of mercury on provocative testing of their urine, giving a false impression that the brain is free of mercury. I must admit that I fell into this trap early on. This may be because mercury in the nervous system is so difficult to remove that very little is chelated during a single test period. This would explain why autistic children improve with chelation even when their urine mercury levels are low. Hair mercury is also a poor measure of brain mercury levels in such cases, one must go by clinical responses.

Diabetes and Neurological Problems

Because of the continual increased production of free radicals and lipid peroxidation in diabetics, it is vital to increase the body's supply of glutathione. Oral glutathione is poorly absorbed and is better supplied by taking N-acetyl L-cysteine (NAC). Alpha-lipoic acid also increases glutathione levels in cells, including brain cells. In addition, alpha-lipoic acid increases energy production and removes excess iron from the tissues (by chelation).

Determination of Inorganic Nitrogen

These determinations are considered to be chemical indexes of availability of nitrogen soil organic matter. The utility of chemical indexes depends on their correlation for a broad range of soils with biological criteria, such as crop yields, nitrogen accumulation in plants, and biological indexes (101). Inorganic nitrogen is determined in an extraction of soil with water or solutions of acids, bases, chelating agents, or salts at differing concentrations and temperatures (101). Severe extractants, such as moderately concentrated (4.5 to 6M) boiling mineral acids or bases, generally give nitrogen releases that correlate well with total soil nitrogen. However, total soil nitrogen as such is not a reliable index of nitrogen availability in soils. Also, release of nitrogen by moderate extraction procedures, such as alkaline permanganate, sodium carbonate, and molar solutions of mineral acids and bases, generally are poorly correlated with biological measurements (96,101). Relatively mild...

Food Use and Comments

Derived from seaweed or dried fish sodium guanylate is a byproduct Calcium disodium and disodium salt of EDTA employed in a variety of foods including soft drinks, alcoholic beverages, dressings, canned vegetables, margarine, pickles, sandwich spreads, and sausage Coloring foods in general, including dietary supplements

Watersoluble vitamins

Thiamin is unstable in alkaline solutions and becomes increasingly unstable as the pH increases. The stability of the vitamin in low pH solutions such as fortified fruit drinks is very good. In common with that of some other vitamins, the stability of thiamin is adversely affected by the presence of copper ions. This effect can be reduced by the addition of metal-chelating compounds such as calcium disodium ethylenediamine tetra-acetate (EDTA). The heavy metals only appear to influence thiamin stability when they are capable of forming complex anions with constituents of the medium. Work with sequestrants has shown that ethylenediamine tetra-acetate (EDTA) has a significant effect on the reduction of ascorbic acid oxidation, with the optimal level of EDTA required to inhibit the oxidation of vitamin C in blackcurrant juice being a mole ratio of EDTA to Cu + Fe of approximately 2.3.15,16 Unfortunately, EDTA is not a permitted sequestrant for fruit juices in many countries. The amino...

Structure and Composition of Membranes

Thus, in addition to the cell walls (Section 2.2.1) cell membranes are effective barriers to solutes of high molecular weight. Most synthetic chelators such as EDTA (see also Table 2.4) and microbial siderophores as specific chelators of iron (Section 16.5) are of high molecular weight and their rate of permeation is restricted through the

Connection to Amyotrophic Lateral Sclerosis

Als Brain Inflammatory Cytokines

Human studies of mercury's relation to ALS have not made the same strong connection. For example, in a fairly recent examination of fifty-three ALS patients using provocative testing with the mercury chelator DMSA, researchers found no difference between ALS patients and controls in either lead or mercury excretion.81 In truth, this still leaves us short of an answer, since some have suggested that those who are unable to excrete mercury on provocative testing may be at a greater risk of neurological disease than those who secrete greater amounts. We have already seen that the nervous system holds onto mercury much tighter than other tissues and organs, and there is some question as to the ability of even chelation drugs, such as DMSA, to remove mercury from the nervous system.

Treating Aluminum Toxicity

Like most metal toxicities, treatment demands careful attention to numerous factors, such as antioxidant supplementation, chelation, prevention of redistribution of aluminum from the blood to the brain during chelation, and the use of special nutrients to protect the brain during treatment.

Other Things to Remember

Two days before you have your fillings removed, I advise that you take DMSA to lower your tissue and blood levels as low as possible. This chelating medication powerfully binds mercury in your tissues and promotes its elimination in your urine. This should be supervised by a physician trained in the use of the drug. If this chelator is used, you will have to have a test to see that your kidney function is normal (usually a BUN and a creatinine). I emphasize once again all chelation should be supervised by a physician expert in the procedure. Following removal of your fillings, you will have to undergo a prolonged period of chelation using DMSA. I would also recommend continuing all of the supplements I mentioned above throughout your treatment. Because of the difficulty in removing mercury from the nervous system, intermittent treatment over a prolonged period of time will be required. I suggest four days of oral chelation followed by two weeks off. This can be repeated until urine...

Effects of Iron Deficiency on Immunity

T or (4 iron chelation) Although the production of macrophage migration inhibitory factor is reduced in iron-deficient adults (Joynson et al., 1972 Swarup-Mitra and Sinha, 1984), production of IL-1 is not, and macrophage cytotoxicity is only slightly reduced (Table 11.4 Bhaskaram et al., 1989). In vitro iron chelation by desfer-rioxamine led to reduced secretion of tumour necrosis factor (TNF)-a by alveolar macrophages from both healthy non-smokers and smokers, which implies that iron deficiency may reduce the production of this pro-inflammatory cation to the plasma membrane in murine spleen lymphocytes and human T-cell lines are impaired by iron deficiency (Alcantara et al., 1991, 1994 Kuvibidila et al., 1991, 1999 Fig. 11.3). Furthermore, iron chelation reduces production of mRNA for protein kinase C (Alcantara et al., 1991, 1994). One early event in T-cell activation pathways that is also reduced by iron deprivation is the hydrolysis of cell-membrane...

Meat and micronutrients Iron in meat

The enhancing effect of meat on non-haem iron bioavailability is commonly referred to as the 'meat factor'. The exact mechanism by which the 'meat factor' works still remains unknown despite the fact that numerous efforts have concentrated on this topic. Research indicates that the mechanism of the 'meat factor' may not be due solely to a single factor but due to a number of contributing factors which work together promoting non-haem iron bioavailability. These factors include the release of cysteine-rich small molecular weight peptides during the proteolysis of meat the ability of these peptides to reduce ferric iron to the more soluble ferrous iron the chelation of soluble non-haem iron by these peptides and the ability of meat to promote gastric acid secretion and gastrin release better than other food components do (Mulvihill, 1996).

Mercury Exposure and Parkinsons Disease

Mercury Detoxification Diagram

In one case report, a female dentist, age forty-seven, developed Parkinson's disease within eighteen months of the onset of her first symptoms.99 Her baseline urinary mercury was 46 ug. With chelation using penicillamine, it increased to 79 ug and then continued to fall during the week of treatment. During the period of the treatment, she improved clinically and then stabilized. It was noted that this represented a new possible cause of Parkinson's disease in the absence of other signs of mercury poisoning. Penicillamine is not the best choice for chelating agents, especially for removal from the brain. In addition, the treatment period was too short and should have included a more complete program for mercury toxicity reduction.

Clearing the Body of Lead

One of the problems with chelating lead is that during early stages of treatment, blood levels can actually increase due to release of lead from bone. Care must be taken to remove this newly released lead quickly so that it isn't redistributed to another organ or the nervous system. Furthermore, removal of toxic metals, especially from the nervous system is not an easy matter. Very exacting methods are required for proper chelation of each metal. The most effective way to remove lead from the body is by DMSA chelation. Like mercury, DMS A binds very tightly to lead and allows the kidneys to flush it out into the urine, but the greatest difference between lead and mercury chelation is that mercury is not stored in the bone. An early consequence of lead chelation is the rebound effect, caused by lead leaving the bones once chelation has begun. With DMSA, after an initial drop, blood lead levels will rise and may be higher after chelation has begun than they were in the beginning. As a...

Dementia

One of the first things I do is give them a trial of some vitamins and minerals by injection and often that will be very helpful. In addition, I have been using EDTA chelation therapy because by using disodium EDTA with magnesium, we find that we're able to reverse some of the aging processes by removing calcium from soft tissues, where it doesn't belong, and trying to get it back into the bone, where it does belong. The chelation process, which is an intravenous treatment, will help with soft tissue decalcification, in addition to removing heavy metals. There is some research relating aluminum toxicity Alzheimer's disease. Dr. Krapper McCloughlin has done some work in Canada, and we have been doing some work recently too, with patients who suffer from dementia, using another chelating agent called Dephoroximine or Desphoral, which is primarily useful in removing iron and aluminum--and not calcium--from the body. Usually, dementia is a one-way street people tend to get worse and...

Toxicity

Wilson's disease is a rare inherited disorder of copper storage (affecting 1 in 200000 people), in which biliary excretion of copper is impaired.12 This results in accumulation of copper in the liver and brain that can lead to cirrhosis, liver failure, and neurologic damage. If diagnosed early and treated with regular copper chelation (using penicil-lamine together with zinc), damage can be avoided.

Flavonoids

As metal chelators, flavonoids show powerful effects against iron and copper, two of the most powerful generators of destructive free radicals, especially in the brain. In fact, it has been hypothesized that the free radicals generated by aluminum, mercury, and lead may be secondary to the fact that they trigger the release of iron from its storage molecule. If true, then flavonoids would play a dual role in protecting the nervous system from free-radical injury directly as antioxidants, and indirectly by chelating iron and copper. Direct chelation of mercury by flavonoids has not been examined.

Testing

Have a twenty-four-hour urine test for mercury excretion or a stool mercury test. This is done without chelation to see how much mercury is being released on a daily basis. Also, if the mercury levels are extremely high, provocative testing may go beyond the measuring capability of the test.

Phytic Acid

Negatively charged molecule which can bind ions of Ca, Mg, and Zn. By virtue of its ability to chelate iron, phytic acid is a potent inhibitor of iron-driven hydroxyl radical formation. Phytic acid also complexes with protein and starch molecules under physiological pH conditions, and hence may be regarded as an antinutrient. Nonetheless, recent evidences suggest that phytic acid has healthful properties. Reduction in glycemic response to starchy foods, as well as lowering of plasma cholesterol and triacylglycerol levels, have been observed with endogenous phytate consumed in foods. In addition, phytic acid has anticancer effects in the colon and mammary glands in rodent models and in various tumor cell lines (Rickard and Thompson, 1997). Furthermore, beneficial effects of phytic acid in relation to cardiovascular disease have been attributed to its hypocholesterolemic properties and chelation of metal ions that inhibits oxidation.

What to Drink

Another way red wine may reduce atherosclerosis is by the action of flavonoids, such as catechin, epicatechin, and quercetin, to bind free iron. In humans, drinking red wine, especially with bread, significantly inhibits iron absorption.371 This is an important property since as we age we absorb and retain more iron in our tissues, which leads to increased free-radical injury. In addition to iron chelation, quercetin which is also found in apples, onions, and tea has been shown to stimulate relaxation of the muscle layer (smooth muscle) in blood vessels, thus improving blood flow.372

Soil Tests

Results of soil analysis, sometimes called total analysis, in which soil mineral and organic matter are destroyed with strong mineral acids, heat, or other agents do not correlate well with crop responses (77). Generally, soil tests involve determination of a form of a plant nutrient with which a variation in amount is correlated with crop growth and yield. These forms of nutrients are commonly called available plant nutrients. The different forms of nutrients are extracted from the soil with some solvent. Many different methods of extraction of soil samples are being used for measurement of available nutrients in soils. Extractants are various combinations of water, acids, bases, salts, and chelating agents at different strengths. The extractants are designed to extract specific nutrients or are universal extractants (77-83). Much discussion has occurred as to whether one method of extraction is better than another. Morgan (77) noted that any chemical method of soil extraction is...

Immune assessment

In addition to assessment of relative percentages of T-cells, B-cells and NK cells, immunophenotyping for activation-antigen expression (e.g. CD69), coex-pression of critical molecules involved in cell-cell interaction (e.g. CD28), T-cell receptor (TCR) changes and percentages of naive and memory cells may be informative. Functional studies should be carried out on fresh anticoagulated blood whenever possible (or blood stored at room temperature in the dark for under 24 h) before mononuclear cells are isolated. When blood is being sent by air or transported to a distant laboratory, it is extremely important to include a control specimen drawn in parallel to serve as an internal standard for the shipping process. In addition, the type of tube chosen to draw the blood is important. Lithium heparin- or ethylenediamine tetra-acetic acid (EDTA)-containing tubes cannot be used for functional studies. Sodium heparin (preservative-free) or acid citrate dextrose (ACD) tubes should be used and...

D Antifungal agents

Unfortunately, relatively high levels of alumi-nosilicates must be used and these provide no other nutrients and may, in fact, act as chelating agents for some essential minerals. However, where aflatoxin contamination is common, then adding up to 15 kg aluminosilicates per tonne of feed may be necessary in order to minimize the effect of this mycotoxin.

Other Precautions

Outside of vascular considerations, and to improve your overall health, do not use fluoride toothpaste, fluoride mouthwashes, or have fluoride treatments by your dentist. Also, if you have dental amalgams ( silver fillings) or crowns with amalgam underneath, you should be tested for mercury, and undergo chelation therapy if necessary. Have amalgam fillings removed by a dentist trained in the approved removal methods (see appendix) and replaced with ceramic.