Lipid metabolism in obesity

Eat Stop Eat

Best Weight Loss Programs That Work

Get Instant Access

Obesity is associated with an increased storage of triglycerides in skeletal muscle (IMTG), accumulation of lipid intermediates (long-chain fatty acyl-CoAs, diacylg-lycerols, and ceramides) and subsequent insulin resistance. The question then presents itself: Why is there an accumulation of muscle lipids in obesity?

Lipid Accumulation Skeletal Muscle

FIGURE 5.1 Proposed mechanism(s) for insulin resistance in skeletal muscle. DAG, diacylg-lycerols: IMTG, intramyocellular triacylglycerols; PKC, protein kinase C; JNK, c-Jun N terminal kinase; IKK, IkB kinase-; IRS-1/2, insulin receptor substrate 1 and 2; P13K, phos-phatidylinositol 3-kinase; GLUT4, glucose transporter 4; (+), activation; (-), inhibition.

FIGURE 5.1 Proposed mechanism(s) for insulin resistance in skeletal muscle. DAG, diacylg-lycerols: IMTG, intramyocellular triacylglycerols; PKC, protein kinase C; JNK, c-Jun N terminal kinase; IKK, IkB kinase-; IRS-1/2, insulin receptor substrate 1 and 2; P13K, phos-phatidylinositol 3-kinase; GLUT4, glucose transporter 4; (+), activation; (-), inhibition.

Was this article helpful?

0 0
The Most Important Guide On Dieting And Nutrition For 21st Century

The Most Important Guide On Dieting And Nutrition For 21st Century

A Hard Hitting, Powerhouse E-book That Is Guaranteed To Change The Way You Look At Your Health And Wellness... Forever. Everything You Know About Health And Wellness Is Going To Change, Discover How You Can Enjoy Great Health Without Going Through Extreme Workouts Or Horrendous Diets.

Get My Free Ebook


Post a comment