Lipid metabolism in obesity

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Obesity is associated with an increased storage of triglycerides in skeletal muscle (IMTG), accumulation of lipid intermediates (long-chain fatty acyl-CoAs, diacylg-lycerols, and ceramides) and subsequent insulin resistance. The question then presents itself: Why is there an accumulation of muscle lipids in obesity?

Lipid Accumulation Skeletal Muscle

FIGURE 5.1 Proposed mechanism(s) for insulin resistance in skeletal muscle. DAG, diacylg-lycerols: IMTG, intramyocellular triacylglycerols; PKC, protein kinase C; JNK, c-Jun N terminal kinase; IKK, IkB kinase-; IRS-1/2, insulin receptor substrate 1 and 2; P13K, phos-phatidylinositol 3-kinase; GLUT4, glucose transporter 4; (+), activation; (-), inhibition.

FIGURE 5.1 Proposed mechanism(s) for insulin resistance in skeletal muscle. DAG, diacylg-lycerols: IMTG, intramyocellular triacylglycerols; PKC, protein kinase C; JNK, c-Jun N terminal kinase; IKK, IkB kinase-; IRS-1/2, insulin receptor substrate 1 and 2; P13K, phos-phatidylinositol 3-kinase; GLUT4, glucose transporter 4; (+), activation; (-), inhibition.

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