Lipid metabolism in obesity

Obesity is associated with an increased storage of triglycerides in skeletal muscle (IMTG), accumulation of lipid intermediates (long-chain fatty acyl-CoAs, diacylg-lycerols, and ceramides) and subsequent insulin resistance. The question then presents itself: Why is there an accumulation of muscle lipids in obesity?

Lipid Accumulation Skeletal Muscle

FIGURE 5.1 Proposed mechanism(s) for insulin resistance in skeletal muscle. DAG, diacylg-lycerols: IMTG, intramyocellular triacylglycerols; PKC, protein kinase C; JNK, c-Jun N terminal kinase; IKK, IkB kinase-; IRS-1/2, insulin receptor substrate 1 and 2; P13K, phos-phatidylinositol 3-kinase; GLUT4, glucose transporter 4; (+), activation; (-), inhibition.

FIGURE 5.1 Proposed mechanism(s) for insulin resistance in skeletal muscle. DAG, diacylg-lycerols: IMTG, intramyocellular triacylglycerols; PKC, protein kinase C; JNK, c-Jun N terminal kinase; IKK, IkB kinase-; IRS-1/2, insulin receptor substrate 1 and 2; P13K, phos-phatidylinositol 3-kinase; GLUT4, glucose transporter 4; (+), activation; (-), inhibition.

Keep Your Weight In Check During The Holidays

Keep Your Weight In Check During The Holidays

A time for giving and receiving, getting closer with the ones we love and marking the end of another year and all the eating also. We eat because the food is yummy and plentiful but we don't usually count calories at this time of year. This book will help you do just this.

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