Diabetes has been associated with the development of erectile dysfunction since 1798 (89). The OR of having erectile dysfunction if a man is diabetic is 1.9 to 4 times greater than in men without diabetes, and it is estimated that 25 percent to 75 percent of men with type 1 diabetes will complain of erectile dysfunction (89). There is an age association with the development of erectile dysfunction, with 15 percent of diabetic men having erectile dysfunction by age 30 and 55 percent by age 60 (89). The mechanism of diabetes-induced erectile dysfunction is multifactorial (89). Related causes include smooth-muscle dysfunction, endothelial dysfunction, and neuropathic damage (89).
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