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By restoring a healthier body weight, dietary treatment (WR) in OW/OB individuals can provide significant clinical benefits. Unfortunately, the nature of diabetes and its treatment can hinder weight loss and even promote weight gain. This is because the progressive dysfunction of pancreatic B cells and increasing insulin resistance necessitate increasingly higher insulin dosages. This, in turn, promotes weight gain, and in a negative vicious cycle, makes weight loss even more difficult to achieve than for the nondiabetic obese individual (20).

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