Inhibition of Cellular Replication

Via Perillyl Alcohol

Dividing cells undergo a series of steps of well-defined cellular changes referred to as the cell cycle. Mitogenic growth signals are required for cells to move from the resting or quiescent state G0 to the proliferative state, defined by a successive series of phases initial gap G1 , DNA synthesis S , second gap G2 , and mitosis M . Each step is characterized by distinct cellular processes that are required for proper cell division. The formation of cyclin a structural protein with a...

Vitamin E Analogs as Anticancer Agents

Jiri Neuzil, Xiu-Fang Wang, Yan Zhao, and Kun Wu 6.2 Vitamin E as an Anticancer Agent More than an Antioxidant 113 6.3 Vitamin E Analogs The Importance of 6.3.1 Structure-Function 6.3.2 Vitamin E Analogs as Anticancer 6.3.3 Selectivity of VE Analogs Increases Their Clinical 6.3.4 VE Analogs Overcome Resistance of Mutant Cancer Cells to Apoptosis, Induce the Mitochondrial Apoptotic Pathway, and Cooperate with Immunological 6.3.5 Vitamin E Analogs as Antitumor Agents Beyond 6.3.6 Pharmacokinetics...

Bioactive Dietary Components

All classical nutrient categories consist of bioactive dietary components, including carbohydrates, amino acids, fatty acids and structural lipids, minerals, and vitamins. In addition is an extensive list of non-nutrient components, particularly phytochemicals, which can have anticancer activity. Phytochemicals are components of a plant-based diet that possess substantial anticarcinogenic and antimu-tagenic properties.7 An estimated 25,000 different chemical compounds occur in fruits,...

Increased Response to Antigrowth Signals and Induction of Differentiation

Normal cells within tissues are also responsive to antiproliferative signals that serve to maintain cellular quiescence and tissue homeostasis. These antigrowth signals are soluble factors or inhibitors embedded in the extracellular matrix. Signals are transmitted to the nucleus via intracellular signaling circuits that are in a balance with the positive growth signals. One of the most prominent negative growth signals in many cell types is TGF-P .26 Most antigrowth signals act on the tumor...

Production Of Phytoene In Mammalian Cells

4.4.1 Establishment of Phytoene-Producing Mammalian Cells and Analysis of Their Properties Phytoene, which is detectable in human blood, was proved to suppress tumori-genesis in skin cancer models. It has been suggested that the antioxidative activity of phytoene may play an important role in its mechanism of action. To confirm the mechanism, more precise study should be carried out. However, phytoene becomes unstable when it is purified, and thus is very difficult to examine its biological...

References

The principles of nutritional oncology. In Heber D, Blackburn G, Go V, eds. Nutritional Oncology. San Diego, CA Academic Press 1999 1-10. 2. World Cancer Research Fund and American Institute for Cancer Research. Food, Nutrition and the Prevention of Cancer A Global Perspective. Washington, DC American Institute for Cancer Research 1997. 3. Ferlay J, Bray F, Pisani P, Parkin D. GLOBOCAN 2002 Cancer Incidence, Mortality and Prevalence Worldwide. 2004. IARC Press....

Contributors

Department of Exercise and Nutrition Sciences Professions State University of New York at Medicine School of Public Health and Health Professions State University of New York at Toxicology School of Medicine and Biomedical Sciences State University of New York at Department of Molecular Pathology Division of Pathology and Laboratory Medicine M.D. Anderson Cancer Center University of Texas Houston, Texas Department of Cancer Biology M.D. Anderson Cancer Center University of Texas Houston, Texas...

Pathogenesis Of Cancer Acquired Capabilities

Neoplasia Diagram

Research over the past 25 years has produced a deeper understanding of the molecular, biochemical, and cellular changes that occur as cells are transformed from normal cells to malignant cancers. The multiple genetic defects leading to cancer cell production can result from exposure to environmental, dietary, and lifestyle factors, as well as infectious agents. The multistep, multistage process of gradual carcinogenetic changes in the biological behavior of a clonogenic population of cells is...

Days of Treatment

Apo Trail Dr4 Apoptosis

FIGURE 6.3 Antimesothelioma effects of a-tocopheryl succinate. A Immunocompro-mised mice were injected intraperitoneally i.p. with human mesothelioma cells and peritoneal mesotheliomas allowed to established. On week 4 after the animals were injected with the cells, treatment was initiated consisting of i.p. administration of 200 ll of 200 M a-TOS in DMSO every third day for more than 20 weeks. Survival was used as a marker for the effect of a-TOS. Adapted from Reference 16. B Immunocompromised...