Methionine Catabolism and Its Relation to Wool Growth

In mammals Met is catabolized mainly through the S-adenosylmethionine pathway, and then diverted either to the aminopropyla-tion pathway for synthesis of polyamines (spermidine and spermine) or to the transsul-phuration pathway for synthesis of homocysteine (HomoCys). HomoCys is used either for synthesis of Cys or is remethylated to re-form Met. Some Met is catabolized through the transamination pathway (Cooper, 1983). A diagram for the simplified catabolic pathways of Met is shown in Fig. 17.1. The control and regulation of the metabolic pathways have been reviewed (e.g. Stipanuk, 1986; and Finkelstein, 1990).

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