Cellular metabolism

Evidence strongly suggests that amino acids are channelled either from extracellular sources or from protein degradation directly to protein synthetic machinery without mixing with intracellular amino acids and being exposed to enzymes involved in amino acid oxidation. Thus, the extent of amino acid channelling may be a critical determinant of the fate (oxidation versus protein synthesis) of amino acids arriving from the digestive tract and those arriving from the turnover of existing proteins.

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